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KMID : 0371320030640010039
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Journal of the Korean Surgical Society
2003 Volume.64 No. 1 p.39 ~ p.43
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The Clinical Significance of Cyclooxygenase 2 Expression in Colorectal Cancer
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Jang Hyun-Rok
Bae Byung-Noe
Yang Keun-Ho
Han Se-Hwan
Kim Hong-Ju
Kim Hong-Yong
Kim Young-Duck
Kim Ki-Whan
Kim Jung-Yoen
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Abstract
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Purpose: Epidemiologic studies have indicated that the use of nonsteroidal anti-inflammatory drugs, which inhibit cyclooxygenase activity, reduce the risk of colorectal cancer. In addition, several studies have demonstrated the increased expression of cyclooxygenase-2 (COX-2) in human colorectal cancer tissues. However, the role of COX-2 in colorectal cancer has not been fully established. The aim of this study was to clarify the clinicopathologic significance of COX-2 expression in human colorectal cancer.
Methods: We performed immunohistochemical straining for COX-2 expression in 124 human colorectal cancer specimens. COX-2 expression was then compared with clinicopathologic factors and survival outcomes.
Results: COX-2 was expressed in the cytoplasm of the cancer cells. COX-2 expression was noted in 86.3% of the cancer patients and significantly correlated with the histologic type. The depth of invasion ,tumor size, lymph node metastasis and stage were not correlated with COX-2 expression. Multivariate analysis for the factors associated with survival showed that serum CEA, size, depth and lymph node involvement correlated with survival, but COX-2 expression had no correlation.
Conclusion: These data suggest that COX-2 expression in primary lesion of colorectal cancer may not be a useful marker for evaluating prognosis. However, further studies are necessary for identification of the roles in colorectal
carcinogenesis.
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KEYWORD
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Cyclooxygenase-2 (COX-2), Colorectal cancer, Immunohistochemistry
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